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KMID : 1149220090170020111
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Korean Journal of Oriental Medical Prescription
2009 Volume.17 No. 2 p.111 ~ p.121
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The Efficacy of Ampule Containing Herbal Extract for Improving Skin Wrinkles in Women
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Do Eun-Ju
Lee Jin-Sang
Park Hyun-Jin
Ha Il-Do
Kim Young-Chul
Kim Mi-Ryeo
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Abstract
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Objectives : This study was performed to evaluate the efficacy of ampule containing herbal extract(Ulmus davidiana, Ginkgo biloba, Perilla ocymoides, Morus alba, Glycyrrhiza uralensis (licorice), and Angelica gigas) on skin wrinkles in adult women with facial wrinkles.
Methods : A total of 12 women, 30 to 46 years of age, with wrinkles in the corner of eyes, applied ampule containing herbal extract twice daily for up to 12 weeks. Silicon replicas of right crow’s feet area and antecubital fossa were taken before use of test product and at 4, 8 and 12 weeks. The replicas were analyzed by optical profilometry with Skin Visiometer SV600. The wrinkle and roughness parameters, R1, R2, R3, R4 and R5 were calculated and statistically analyzed. In addition, a subjective evaluation of product efficacy was conducted by patient’s assessment.
Results : The mean values of all the skin roughness parameters were decreased at 4-week, and decreased significantly at 8 and 12-week except R4 at 12-week after test product use. The subjective evaluation of wrinkle by patient’s assessment was also improved. However, one patient noted stiffness of face after use of test product.
Conclusions : These study suggested that the application of ampule containing herbal extract twice daily for 12 weeks may effectively improve the facial wrinkles without severe side effect.
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KEYWORD
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wrinkle, herbal extract, crow’s feet, profilometry, skin roughness
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